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2-AMİNO-l,3,4-TİYADİAZOL VE 2-AMİNO-5-NİTROTİYAZOLUN BAZI REAKSİYONLARININ İNCELENMESİ
2-AMİNO-l,3,4-TİYADİAZOL VE 2-AMİNO-5-NİTROTİYAZOLUN BAZI REAKSİYONLARININ İNCELENMESİ
Muzaffer Alkan, Haydar Yüksek, Murat Beytur
Volume : 1  Issue : 1  Pages : 123-128  Year : 2014

Abstract
In this study, thiadiazole type heterocyclic compounds were obtained from the reactions of 2-amino-1,3,4-thiadiazole with 3-nitrophytalic anhydride, cis-1,2,3,6-terahydrophytalic anhydride and 1,8-naphtalic anhydride. On the other hand, from the reaction of 2-amino-1,3,4-thiadiazole with cis-hexahydrophytalic anhydride, diamide derivative was obtained.
In the second part of the study, from the reaction of 2-amino-1,3,4-thiadiazole with succinic anhydride, a monoamide compound was obtained. Then, 2-amino-1,3,4-thiadiazole were reacted with 2,5-dimethoxytetrahydrofuran, 2-(1-pirrolyl)-5-nitrothiazol was synthesized.
As a result, structures of these new biological active compounds were characterized by main of combustion analyses, IR, UV and 1H NMR spectral methods and synthesis mechanisms were explained.


Keywords : 2-amino-1,3,4-thiadiazole, 3-nitrophytalic anhydride, cis-1,2,3,6-terahydrophytalic anhydride, 1,8-naphtalic anhydride.
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