2-AMİNO-l,3,4-TİYADİAZOL VE 2-AMİNO-5-NİTROTİYAZOLUN BAZI REAKSİYONLARININ İNCELENMESİ
2-AMİNO-l,3,4-TİYADİAZOL VE 2-AMİNO-5-NİTROTİYAZOLUN BAZI REAKSİYONLARININ İNCELENMESİ Muzaffer Alkan, Haydar Yüksek, Murat Beytur Volume : 1 Issue : 1 Pages : 123-128 Year : 2014
Abstract In this study, thiadiazole type heterocyclic compounds were obtained from the reactions of 2-amino-1,3,4-thiadiazole with 3-nitrophytalic anhydride, cis-1,2,3,6-terahydrophytalic anhydride and 1,8-naphtalic anhydride. On the other hand, from the reaction of 2-amino-1,3,4-thiadiazole with cis-hexahydrophytalic anhydride, diamide derivative was obtained.
In the second part of the study, from the reaction of 2-amino-1,3,4-thiadiazole with succinic anhydride, a monoamide compound was obtained. Then, 2-amino-1,3,4-thiadiazole were reacted with 2,5-dimethoxytetrahydrofuran, 2-(1-pirrolyl)-5-nitrothiazol was synthesized.
As a result, structures of these new biological active compounds were characterized by main of combustion analyses, IR, UV and 1H NMR spectral methods and synthesis mechanisms were explained.